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Li-Fraumeni syndrome
3 OMIM references -
2 associated genes
16 signs/symptoms
PROTEIN INTERACTIONS: 1
Follicular lymphoma
1 OMIM reference -
4 associated genes
14 signs/symptoms
Li-Fraumeni syndrome
Follicular lymphoma

CHEK2
(UniProt - OMIM)
 BCL2
(UniProt - OMIM)
TP53
(UniProt - OMIM)
 BCL6
(UniProt - OMIM)
HLA-DRB1
(UniProt - OMIM)
IGH
(UniProt)

INTERACTOME
ASSOCIATIONS
(click on a score value to see the evidence)
TP53
(0.86)
BCL2


Citations in the biomedical literature:


Li-Fraumeni syndrome
CHEK2 TP53
Follicular lymphoma
BCL2 BCL6 HLA-DRB1 IGH



Li-Fraumeni syndrome
Follicular lymphoma

Classification (Orphanet):
- Rare endocrine disease
- Rare genetic disease
- Rare neurologic disease
- Rare oncologic disease
Classification (Orphanet):
- Rare hematologic disease
- Rare oncologic disease
Classification (ICD10):
- Neoplasms -
Classification (ICD10):
- Neoplasms -
Epidemiological data:
Class of prevalence: unknown
Average age onset: adulthood
Average age of death: -
Type of inheritance: autosomal dominant
Epidemiological data:
Class of prevalence: 1-5 / 10 000
Average age onset: adulthood
Average age of death: adult
Type of inheritance: multigenic/multifactorial
External references:
3 OMIM references -
1 MeSH reference: D016864
External references:
1 OMIM reference -
1 MeSH reference: D008224
Li-Fraumeni syndrome
Follicular lymphoma

Very frequent
- Acute leukemia
- Autosomal dominant inheritance
- Bone / osseous neoplasm / tumor / carcinoma / cancer
- Breast neoplasm / tumor / carcinoma / cancer
- Central nervous system / peripheral nerves neoplasm / tumor / carcinoma / cancer
- Colon neoplasm / tumor / carcinoma / cancer
- Cortical adrenal neoplasm / tumor / carcinoma / cancer
- Lymphoma
- Neoplasms / tumors
- Pancreatic / pancreas neoplasm / tumor / carcinoma / cancer
- Sarcoma
- Skin / cutaneous neoplasm / tumor / carcinoma / cancer (excluding melanoma)
- Soft tissue sarcoma / cancer / tumor / liposarcoma / myosarcoma

Occasional
- Lung / bronchopulmonary neoplasm / tumor / carcinoma / cancer
- Melanoma
- Oropharyngeal neoplasm / tumor / carcinoma / cancer


Very frequent
- Fever / chilling
- Hematologic / blood / lymphatic cancer
- Hyperhidrosis / increased sweating
- Lymphadenopathy / polyadenopathies
- Weight loss / loss of appetite / break in weight curve / general health alteration

Frequent
- Asthenia / fatigue / weakness
- Mediastinal / hilar adenopathies
- Splenomegaly

Occasional
- Abnormal pleura / hydrothorax / pleuresia / pleural effusion / chylothorax
- Anomalies of skin, subcutaneous tissue and mucosae
- Bone marrow / medullar infiltration
- Lymphedema
- Meningitis / meningeal syndrome
- Structural anomaly of the peritoneum